Early Warning and Rapid Public Health Response to Prevent COVID-19 Outbreaks in Long-term Care Facilities (LTCF) by Monitoring SARS-CoV-2 RNA in LTCF Site-specific Sewage Samples and Assessment of Antibodies Response in this Population
There are two parts to this study:
* Part I: Sewage SARS-CoV-2 surveillance as early warning system and public health response;
* Part II: COVID-19 Immunity Study
The objectives of this study are to:
* Study the utility and feasibility of long-term care facilities (LTCF) site-specific sewage surveillance of SARS-CoV-2 as an early warning system for COVID-19 that is coupled with rapid Public Health notification and response to prevent outbreaks in LTCF. (Part I)
* Do the cost-benefit analysis of this early warning system. (Part I)
* Study antibody response to COVID-19 among staff and residents of LTCF, stratified by their exposure to and history of infection with COVID-19 during outbreaks and immunizations. (Part II)
* Evaluate the performance of multiple commercial assays to detect vaccine-induced antibodies and correlation with neutralizing antibody responses. (Part II)
Overview
- Acronym
- SSSIS
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2021 - 2022
- General Information on Follow Up (profile, frequency)
-
In Part I of the study, sewage samples from LTCF are monitored twice per week for SARS-CoV-2. If the sewage sample is tested negative, then no action will be taken. Positive sewage results may trigger investigations as deemed appropriate by Public Health. In Part II, staff and residents of different LTCF, some with and some without sewage monitoring, were enrolled for an immunity study were followed up at various time points pre-vaccine, pre-second dose, 3-, 6-, 12- and 18-months post second dose for antibodies testing.
- Recruitment Target
-
- Individuals
- Number of Participants
- 500
- Number of Participants with Biological Samples
- 500
- Supplementary information about number of participants
-
500 consenting LTCF staff and residents will be recruited.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Papers
Lee BE, Sikora C, Faulder D, et al. Early warning and rapid public health response to prevent COVID-19 outbreaks in long-term care facilities (LTCF) by monitoring SARS-CoV-2 RNA in LTCF site-specific sewage samples and assessment of antibodies response in this population: prospective study protocol. BMJ open. 2021; 1;11(8):e052282.
PUBMED 34417219Timeline
Populations
SSSIS - Sewage tested Positive- No recent or active COVID-19 cases
The population is composed of residents, staff, and visitors of LTCFs, from where sewage samples tested positive for SARS-CoV-2, and where there weren't recent or active COVID-19 cases.
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- Alberta
- Territory
- Edmonton
Sources of Recruitment
- Specific Population
-
- Other specific population : Residents from LTCFs' water samples tested positive for SARS-CoV-2
- Supplementary Information
-
Ten stand-alone LTCF with various histories of COVID-19 outbreaks and feasible access to site-specific sewage were selected for the sewage surveillance study after review by EPCOR, the lead MOH of Edmonton zone and the Medical Director of Continuing Care, Edmonton zone. Participants were selected based on the positive SARS-CoV-2 water sample at the LTCFs.
Sample Size
- Number of Participants
- No Limit
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | SSSIS - Sewage tested Positive-No recent or active COVID-19 cases - Outbreak investigation |
|
|
2021 | 2022 |
SSSIS - Sewage tested Positive- Recent or active COVID-19 cases
The population is composed of residents, staff, and visitors of LTCFs, from where sewage samples tested positive for SARS-CoV-2, and where there were recent or active COVID-19 cases.
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- Alberta
- Territory
- Edmonton
Sources of Recruitment
- Specific Population
-
- Other specific population : Residents from LTCFs' water samples tested positive for SARS-CoV-2
- Supplementary Information
-
Ten stand-alone LTCF with various histories of COVID-19 outbreaks and feasible access to site-specific sewage were selected for the sewage surveillance study after review by EPCOR, the lead MOH of Edmonton zone and the Medical Director of Continuing Care, Edmonton zone. Participants were selected based on the positive SARS-CoV-2 water sample at the LTCFs.
Sample Size
- Number of Participants
- No Limit
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 1 | SSSIS - Sewage tested Positive- Recent or active COVID-19 cases - Outbreak investigation |
|
|
2021 | 2022 |
SSSIS - Vaccine immunity residents
The population is composed of residents of LTCF who have agreed to participate in the immunity study in Edmonton, Alberta.
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- Alberta
- Territory
- Edmonton
Sources of Recruitment
- Specific Population
-
- Other specific population : LTCF Residents
- Supplementary Information
-
An infographic and a letter of invitation was circulated to three professional membership bodies for continuing care providers in Alberta, namely Alberta Continuing Care Association, Alberta Seniors Communities and Housing Association, and the Christian Health Associa-tion of Alberta, asking for the information to be distrib-uted to their members to solicit interest in the study.
Sample Size
- Number of Participants
- 250
- Number of Participants with Biological Samples
- 250
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | SSSIS - Vaccine immunity residents - Baseline |
|
|
2021 (February) | Ongoing |
| 1 | SSSIS - Vaccine immunity residents - Pre-vaccine |
|
|
2021 (February) | Ongoing |
| 2 | SSSIS - Vaccine immunity residents - Pre-second dose |
|
|
2021 (February) | Ongoing |
| 3 | SSSIS - Vaccine immunity residents - 3-month post second dose |
|
|
2021 (August) | Ongoing |
| 4 | SSSIS - Vaccine immunity residents - 6-month post second dose |
|
|
2021 (November) | Ongoing |
| 5 | SSSIS - Vaccine immunity residents - 12-month post second dose |
|
|
2022 (May) | Ongoing |
| 6 | SSSIS - Vaccine immunity residents - 18-month post second dose |
|
|
2022 (November) | Ongoing |
SSSIS - Vaccine immunity staff
The population is composed of staff of LTCF who have agreed to participate in the immunity study in Edmonton, Alberta.
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- Alberta
- Territory
- Edmonton
Sources of Recruitment
- Specific Population
-
- Other specific population : LTCF Staff
- Supplementary Information
-
An infographic and a letter of invitation was circulated to three professional membership bodies for continuing care providers in Alberta, namely Alberta Continuing Care Association, Alberta Seniors Communities and Housing Association, and the Christian Health Associa-tion of Alberta, asking for the information to be distrib-uted to their members to solicit interest in the study.
Sample Size
- Number of Participants
- 250
- Number of Participants with Biological Samples
- 250
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | SSSIS - Vaccine immunity staff - Baseline |
|
|
2021 (February) | Ongoing |
| 1 | SSSIS - Vaccine immunity staff - Pre-vaccine |
|
|
2021 (February) | Ongoing |
| 2 | SSSIS - Vaccine immunity staff - Pre-second dose |
|
|
2021 (February) | Ongoing |
| 3 | SSSIS - Vaccine immunity staff - 3-month post second dose |
|
|
2021 (August) | Ongoing |
| 4 | SSSIS - Vaccine immunity staff - 6-month post second dose |
|
|
2021 (November) | Ongoing |
| 5 | SSSIS - Vaccine immunity staff - 12-month post second dose |
|
|
2022 (May) | Ongoing |
| 6 | SSSIS - Vaccine immunity staff - 18-month post second dose |
|
|
2022 (November) | Ongoing |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2024-02-27T15:55:38.375