Signature Biobank - Banks of biological, psychosocial and clinical data on people suffering from mental health problems
Overview
- Acronym
- SIGNATURE
- Website
- SIGNATURE
- Investigators
-
Dr. Stéphane GuayCentre de recherche de l'Institut universitaire en santé mentale de Montréal (CR-IUSMM)
- Contacts
-
Dr. Cécile Le PageCentre de recherche de l’Institut universitaire en santé mentale de Montréal (CR-IUSMM)
General Design
- Study design
- Cohort
- Start - End Year
- 2012 - 2021
- General Information on Follow Up (profile, frequency)
-
**Mental Health Patients** Participants are followed-up at 4 different points in their clinical journey, ie. when entering the emergency room, during treatment in an inpatient unit and during recovery in an outpatient clinic. **Controls** After first recruitment, a sub-group of participants are followed up for a second time within a month.
- Recruitment Target
-
- Individuals
- Number of Participants
- 2,322
- Number of Participants with Biological Samples
- 2,135
- Supplementary information about number of participants
-
* Mental health patients: 2173 participants * Mental health patients with biosamples: 1986 participants * Controls: 149 partipants * Controls with biosamples: 149 participants
- Supplementary Information
-
Study designs: Cohort and case-control
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Data can be accessed upon request to the biobank coordinator.
- On the study website : https://criusmm.ciusss-estmtl.gouv.qc.ca/fr/pro...
- By contacting the study representative: Biobank Coordinator Cecile Le Page (Institution CR-IUSMM)
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
Researchers from the private sector needs to be a collaborator of one of the Signature consortium members.
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
| Can leave the study facility | ||
| Can leave the country |
Cost
| Possible Access to Data | Fixed Cost |
| Possible Access to Biosamples | Fixed Cost |
Biological sample prices range from $20 to $40 per sample.
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Members of the Alliance santé mentale au Québec benefit from a reduction.
Marker Papers
S.J. Lupien, M. Sasseville, N. Francois, et al. Lesage and Signature Consortium. Stress 20, 2-18 (2017)
PUBMED 28124571E. Cipriani, P. Kerr, C. Le Page, et al. Biobanque Signature : origines et perspectives d’un projet longitudinal évaluant les signatures biologiques, psychologiques et sociales des patients visitant les urgences de l’Institut universitaire en santé mentale de Montréal. Santé mentale au Québec Vol. 49, n 2, Fall 2024, p. 173–201
P. Kerr, C. Le Page, C.-É.Giguère, S. Lupien, et al. The Signature Biobank: A longitudinal biopsychosocial repository of psychiatric emergency patients. Psychiatry Research. Vol. 332, Feb 2024, 115718
Supplementary Information
V. Laliberté, C.-É. Giguère, S. Potvin, A. Lesage. Berkson's bias in biobank sampling in a specialized mental health care setting: a comparative cross-sectional study. BMJ Open 10(7):35088 July 2020
S. Potvin, L. Mahrouche, R. Assaf, et al. Furtos, R.Godbout on behalf of the Signature Consortium. Peripheral Endogenous Cannabinoid Levels Are Increased in Schizophrenia Patients Evaluated in a Psychiatric Emergency Setting. Front. Psychiatry, 30 June 2020
T. Lecomte, C.-É. Giguère, B. Cloutier, S. et al.Comorbidity Profiles of Psychotic Patients in Emergency Psychiatry. Journal of Dual Diagnosis, 2020 Jan Vol.16 (issue2) 260:270
M.-F. Marin, S. Geoffrion, C.-É. Giguère, et al.The Moderating Role of Age in the Relationship Between Early Life Adversity and Hair Cortisol Concentrations in Adults Admitted to a Psychiatric Emergency Service. Biological Psychiatry, 2019 May 85(10): S146-S147
Timeline
Populations
Selection Criteria
- Minimum age
-
18
- Maximum age
-
81
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Montreal
- Health Status
-
- Participants are patients who had a mental crisis.
- Other Criteria
- Participants admitted to one of two programs targeted by the project: the anxiety and mood disorder (AMD) program or the first psychotic episode (FPE) program are elligibale for the second (T2), third (T3) and fourth (T4) follow up. Pregnant women are excluded.
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Patients were recruited from the psychiatric emergency of the Hôpital Louis Lafontaine emergency room.
Sample Size
- Number of Participants
- 2,173
- Number of Participants with Biological Samples
- 1,986
- Supplementary information about number of participants
-
**Mental Health Patients T1** * 2,173 participants * 1,986 biological samples **Mental Health Patients T2** * 885 participants * 885 biological samples **Mental Health Patients T3** * 793 participants * 779 biological samples **Mental Health Patients T4** * 473 participants * 473 biological samples
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | SIGNATURE - Mental Health Patients - T1 |
|
|
2012 (November) | 2020 (March) |
| 1 | SIGNATURE - Mental Health Patients - T2 |
|
|
2013 (January) | 2020 (March) |
| 2 | SIGNATURE - Mental Health Patients - T3 |
|
|
2013 (January) | 2020 (October) |
| 3 | SIGNATURE - Mental Health Patients - T4 |
|
|
2014 (February) | 2021 (March) |
Selection Criteria
- Minimum age
-
18
- Maximum age
-
81
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- East part of the Montreal Island
- Other Criteria
- The control group was locally recruited to match age, sex and economic status of the patient cohort. Pregnant women are excluded.
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Supplementary Information
-
Participants are voluntary patients recruited within the communities of the eastern part of the Montreal Island.
Sample Size
- Number of Participants
- 149
- Number of Participants with Biological Samples
- 149
- Supplementary information about number of participants
-
A sub-group of 30 had a second follow-up T2 (within 1 month after first recruitment).
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | SIGNATURE - Controls - T1 |
|
|
2016 (September) | 2020 (March) |
| 1 | SIGNATURE - Controls - T2 |
|
|
2016 (September) | 2020 (March) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
Areas of Information Collected per per Population and Data Collection Event
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|