Signature Bank - Banks of Biological, Psychosocial and Clinical Data on People Suffering from Mental Health Problems
The objectives of the Signature Bank of medical, psychosocial and human biological material are:
* To advance mental health research,
* To assess the physical and mental health of volunteers admitted to the Montreal Mental Health University Institute.
* To enable clinicians to tailor treatment based on meaningful psychosocial and medical indicators.
It aims to collect, on the one hand, medical and psychosocial data and, on the other hand, human biological material from users consenting to participate in the project and from the brief intervention programs (emergency), the psychotic disorders program and the mood disorders program of the Montreal Mental Health University Institute.
Overview
- Acronym
- SIGNATURE
- Website
- SIGNATURE
- Investigators
-
Dr. Stéphane GuayCentre de recherche de l'Institut universitaire en santé mentale de Montréal (CR-IUSMM)
- Contacts
-
Dr. Cécile Le PageCentre de recherche de l’Institut universitaire en santé mentale de Montréal (CR-IUSMM)
General Design
- Study design
- Cohort
- Start - End Year
- 2012 -
- General Information on Follow Up (profile, frequency)
-
Participants are followed-up at 4 different points in their clinical journey, ie. when entering the emergency room (Emergency group), during treatment in an inpatient unit and during recovery in an outpatient clinic (Longitudinal group).
- Recruitment Target
-
- Individuals
- Number of Participants
- 2,322
- Number of Participants with Biological Samples
- 1,950
- Supplementary information about number of participants
-
Emergency group: Number of participants: 2173 participants Number of participants with biosamples: 2173 participants Longitudinal group: Number of participants: 949 participants Number of participants with biosamples: 850 participants Controls: 149 partipants
- Supplementary Information
-
Study designs: Cohort and case-control
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Papers
S.J. Lupien, M. Sasseville, N. Francois, C.E. Giguere, J. Boissonneault, P. Plusquellec, R. Godbout, L. Xiong, S. Potvin, E. Kouassi, A. Lesage and Signature Consortium. Stress 20, 2-18 (2017)
PUBMED 28124571Supplementary Information
L. Dion-Albert, A. Cadoret, E. Doney, F.Né Kaufmann, K.A. Didek, B. Daigle, L. Parise, F. Cathomas, N. Sama, N. Hudson, M. lebel, Signature Consortium, M. Campbell, G. Tureki, N. Mechawar, C. Menard: Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue. Nat. Com. 13, 64 (2022)
V. Laliberté, C.-É. Giguère, S. Potvin, A. Lesage. Berkson's bias in biobank sampling in a specialized mental health care setting: a comparative cross-sectional study. BMJ Open 10(7):35088 July 2020
S. Potvin, L. Mahrouche, R. Assaf, M. Chicoine, C.-É. Giguère, A. Furtos, R.Godbout on behalf of the Signature Consortium. Peripheral Endogenous Cannabinoid Levels Are Increased in Schizophrenia Patients Evaluated in a Psychiatric Emergency Setting. Front. Psychiatry, 30 June 2020
T. Lecomte, C.-É. Giguère, B. Cloutier, S. Potvin, Signature Consortium.Comorbidity Profiles of Psychotic Patients in Emergency Psychiatry. Journal of Dual Diagnosis, 2020 Jan Vol.16 (issue2) 260:270
M.-F. Marin, S. Geoffrion, C.-É. Giguère, Consortium Signature.The Moderating Role of Age in the Relationship Between Early Life Adversity and Hair Cortisol Concentrations in Adults Admitted to a Psychiatric Emergency Service. Biological Psychiatry, 2019 May 85(10): S146-S147
Timeline
Populations
SIGNATURE - Mental health patients
This population is composed of patients that have been at the emergency room (Emergency group) and admitted to one of two programs targeted by the project: the anxiety and mood disorder (AMD) program or the first psychotic episode (FPE) program (Longitudinal group).
Selection Criteria
- Minimum age
-
18
- Maximum age
-
81
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Montreal
- Health Status
-
- During a mental health crisis
- Other Criteria
- Any patients able to consent admitted at the ER of Louis Lafontaine Hospital and patients (Emergency group) and patients with follow-up for mental health at the IUSMM outpatient clinic, that had sufficient mental capacities to allow informed consent, and that they were legally able to consent for themselves (Longitudinal group).
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Patients were recruited from the psychiatric emergency of the Montreal University Mental Health Institute.
Sample Size
- Number of Participants
- 2,173
- Number of Participants with Biological Samples
- 850
- Supplementary information about number of participants
-
Emergency group: 1224 participants Longitudinal group: 949 participants, 850 participants with biological samples
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | SIGNATURE - Mental health patients - Emergency group - T1 |
|
|
2012 (November) | 2020 (March) |
| 1 | SIGNATURE - Mental health patients - Longitudinal patients - T2 |
|
|
2013 (January) | 2020 (March) |
| 2 | SIGNATURE - Mental health patients - Longitudinal patients - T3 |
|
|
2013 (January) | 2020 (March) |
| 3 | SIGNATURE - Mental health patients - Longitudinal patients - T4 |
|
|
2014 (February) | 2021 (May) |
SIGNATURE - Controls
This population is a Canadian age-matched control group recruited in Montreal East area without any known mental disorder.
Selection Criteria
- Health Status
-
- Participants without any known mental disorder
Sources of Recruitment
- General Population
-
- Volunteer enrolment
Sample Size
- Number of Participants
- 149
- Number of Participants with Biological Samples
- 149
- Supplementary information about number of participants
-
A sub-group of 30 had a second follow-up T2 (within 1 month after first recruitment).
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | SIGNATURE - Controls - T1 |
|
|
2016 (September) | 2020 (October) |
| 1 | SIGNATURE - Controls - T2 |
|
|
2016 (October) | 2017 (July) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2022-05-03T19:12:42.650