Ontario Birth Study
The main objective of the Ontario Birth Study (OBS) is to provide a platform for assessing a wide range of exposures including environmental, diet, social and emotional factors and genetics in relation to outcomes such as pregnancy complications (e.g. preterm birth, pre-eclampsia, IUGR, gestational diabetes, low birth weight, miscarriage), and maternal health (both mental and physical health outcomes during pregnancy and the postpartum period). In addition, the platform will serve as a basis for the study of childhood and later life health outcomes, learning, and social functioning.
More specifically, the OBS study aims to :
- identify informative biomarkers and defined molecular mechanisms responsible for the major pregnancy complications such as growth restriction, pre-eclampsia and preterm birth, placental insufficiency;
- determine how adversity during pregnancy and early life impact the establishment of developmental trajectories to later life health, learning and social functioning;
- promote interventions that seek to optimize individual developmental trajectories, to enhance developmental potential and prevent or mitigate the impact of early adversity.
Overview
- Acronym
- OBS
- Website
- OBS
- Investigators
-
- Contacts
General Design
- Study design
- Cohort
- Start - End Year
- 2013 -
- General Information on Follow Up (profile, frequency)
-
Participants were followed-up at 12-16 weeks, 28-32 weeks, 34-38 weeks of gestation, at delivery and at 6-10 weeks postpartum.
- Recruitment Target
-
- Families
- Number of Participants
- 2,748
- Number of Participants with Biological Samples
- 1,835
- Supplementary information about number of participants
-
Mothers: 1374 participants
Children: 1374 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
- On the study website : http://www.ontariobirthstudy.ca/
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
| Can leave the study facility | ||
| Can leave the country |
'Responsibilities of the Applicant' are outlined in the 'Data Access Application Form'
Cost
| Possible Access to Data | Variable Cost |
| Possible Access to Biosamples | Variable Cost |
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Marker Papers
Anderson LN, Knight JA, Hung RJ, et al. The Ontario Birth Study: A prospective pregnancy cohort study integrating perinatal research into clinical care. Paediatr Perinat Epidemiol. 2018;32:290–301. https://doi.org/10.1111/ppe.12473
PUBMED 29750375Timeline
Populations
OBS - Mothers
The population is composed of pregnant women receiving prenatal care at the obstetrical clinics affiliated with Mount Sinai Hospital and St. Michael's Hospital.
Selection Criteria
- Gender
-
Women only
- Minimum age
-
18
- Pregnant Women
-
- First trimester
- Second trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
- Territory
- Toronto
- Other Criteria
- Women have to be less than 17 weeks gestation, delivering at an OBS Hospital, have antenatal care at an OBS Hospital
- Supplementary Information about selection criteria
-
The exclusion criterias aimed at women who had a non-viable fetus and had known significant abnormalities.
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Women are recruited at the time of their first nuchal translucency scan, ultrasound or prenatal visit at St. Michael's and Mount Sinai Obstetrics clinics, usually at 11-14 weeks of gestational age. Recruitment is ongoing.
Sample Size
- Number of Participants
- 1,374
- Number of Participants with Biological Samples
- 1,325
- Supplementary Information about selection criteria
-
LSQ 1: 1196 participants
LSQ 2: 1171 participants
LSQ 3: 819 participants
DHQ: 1034 participants
Blood 1: 1325 participants
Blood 2: 538 participants
Blood 3: 1015 participants
Blood 4: 815 participants
Swab 1: 1253 participants
Swab 2: 1067 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | OBS - Mothers - 12-16 weeks |
|
|
2013 (January) | 2017 |
| 1 | OBS - Mothers - 16-20 weeks |
|
2013 (February) | 2017 | |
| 2 | OBS - Mothers - 28-32 weeks |
|
|
2013 (April) | 2017 |
| 3 | OBS - Mothers - 34-38 weeks |
|
|
2013 (June) | 2017 |
| 4 | OBS - Mothers - Delivery |
|
|
2013 (July) | 2017 |
| 5 | OBS - Mothers - 6-10 weeks postpartum |
|
2013 (August) | 2017 |
OBS - Children
The population is composed of the children of the women enrolled in the study.
Selection Criteria
- Newborns
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
- Territory
- Toronto
Sources of Recruitment
- Specific Population
-
- Other specific population : Children of the women already recruited in the study
- Supplementary Information
-
Some mothers of the Ontario Birth Study choose to also enroll their children in the TARGet Kids! study.
Sample Size
- Number of Participants
- 1,374
- Number of Participants with Biological Samples
- 510
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | OBS - Children - Birth |
|
|
2013 (July) | 2017 |
| 1 | OBS - Children - 6-10 weeks postpartum |
|
2013 (August) | 2017 |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2024-02-27T15:21:17.361