Maternal-Infant Research on Environmental Chemicals
- The primary objectives of the MIREC Study are:
- to determine whether current non-occupational exposure to heavy metals, such as lead (as measured in maternal and infant biospecimens), is related to elevated maternal blood pressure or fetal growth restriction and
- to obtain national-level contemporary biomarkers of in utero and lactational exposure to priority environmental chemicals (e.g. heavy metals, phthalates, brominated flame retardants, bisphenol A [BPA]).
Overview
- Acronym
- MIREC
- Website
- MIREC
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2008 -
- General Information on Follow Up (profile, frequency)
-
Participants were followed-up at each trimester of pregnancy, at delivery and at post-delivery time points (day 1-2, 2-10 weeks, 6 months, 15 months, 3 years, and 5 years post-partum).
- Recruitment Target
-
- Families
- Number of Participants
- 5,590
- Number of Participants with Biological Samples
- 3,942
- Supplementary information about number of participants
-
Mothers: 1983 participants
Fathers: 1648 participants
Children: 1959 participants
Final sample includes 1983 mothers who completed visit 1 (including 48 multiple pregnancies),1959 livebirths (including 98 babies from the 48 mothers), and 340 fathers.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
- On the study website : http://www.mirec-canada.ca
- By contacting the study representative: Biobank Manager Nicole Lupien (CHU Sainte-Justine)
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
| Can leave the study facility | ||
| Can leave the country |
The restriction is on individual-level data / biological samples can leave the country (choice of laboratory must be justified
Cost
| Possible Access to Data | Variable Cost |
| Possible Access to Biosamples | Variable Cost |
Cost estimate is provided after review of the preliminary application
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Cost is established based on multiple factors, on a case-by-case
Marker Paper
Arbuckle Tye E., Fraser William D., Fisher Mandy et al. Cohort profile: the maternal-infant research on environmental chemicals research platform. Paediatr Perinat Epidemiol. 2013 Jul;27(4):415-2
PUBMED 23772943Timeline
Populations
MIREC - Mothers
This population is composed of women aged 18 years and older and whom are less than 14 weeks pregnant, who were attending prenatal clinics.
Selection Criteria
- Gender
-
Women only
- Minimum age
-
18
- Pregnant Women
-
- First trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Alberta
- British Columbia
- Manitoba
- Nova Scotia
- Ontario
- Quebec
- Territory
-
Vancouver, Edmonton, Winnipeg, Sudbury, Ottawa, Kingston, Hamilton, Toronto, Montreal and Halifax.
- Health Status
-
- Participants were excluded if they:
- had known fetal abnormalities (e.g. hydatidiform mole), or known fetal chromosomal or major malformations in the current pregnancy; and
- had a history of medical complications, including the following: renal disease with altered renal function; epilepsy; any collagen disease, such as lupus erythematosus and scleroderma; active and chronic liver disease (hepatitis); heart disease; serious pulmonary disease; cancer; haematological disorder (patient with anaemia or thombophilias will be included); threatened spontaneous abortion (women with previous bleeding in the first trimester were included if the site documented a viable fetus at the time of recruitment); and illicit drug use.
- Participants were excluded if they:
- Other Criteria
- Participants had to have the ability to consent and to communicate in English or French, be willing to provide a sample of cord blood and be planning on delivering at a local hospital.
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Participants were recruited from the general population who were attending prenatal clinics (ultrasound, midwife and/or doctor's clinics) during the first trimester of pregnancy (6 to 14 weeks). Recruitment took place from 2008 to 2011.
Sample Size
- Number of Participants
- 1,983
- Number of Participants with Biological Samples
- 1,983
- Supplementary information about number of participants
-
Prenatal visit 1: 1983 participants
Prenatal visit 2: 1831 participants
Prenatal visit 3: 1733 participants
Delivery : 1727 participants
Postpartum visit 1 and 2 : 1385
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MIREC - Mothers - Prenatal Visit 1 |
|
|
2008 (February) | 2011 (March) |
| 1 | MIREC - Mothers - Prenatal Visit 2 |
|
|
2008 (May) | 2011 (June) |
| 2 | MIREC - Mothers - Prenatal Visit 3 |
|
|
2008 (July) | 2011 (September) |
| 3 | MIREC - Mothers - Delivery |
|
|
2008 (September) | 2011 (October) |
| 4 | MIREC - Mothers - Postpartum Visit 1 |
|
2008 (September) | 2011 (October) | |
| 5 | MIREC - Mothers - Postpartum Visit 2 |
|
|
2008 (October) | 2012 (April) |
| 7 | MIREC - Mothers - MIREC-ID 6 months |
|
2010 (August) | 2012 (May) | |
| 8 | MIREC - Mothers - MIREC-CD3 |
|
2012 (August) | 2014 (March) | |
| 9 | MIREC - Mothers - MIREC-CD Plus |
|
2013 (March) | 2015 (March) | |
| 10 | MIREC - Mothers - MIREC-ENDO |
|
|
2018 (January) | Ongoing |
MIREC - Children
The population is composed of the MIREC mothers’ newborn children (live births).
Selection Criteria
- Newborns
- Countries
-
- Canada
- Canadian Provinces
-
- Alberta
- British Columbia
- Manitoba
- Nova Scotia
- Ontario
- Quebec
- Territory
-
Vancouver, Edmonton, Winnipeg, Sudbury, Ottawa, Kingston, Hamilton, Toronto, Montreal and Halifax.
Sources of Recruitment
- Specific Population
-
- Other specific population : Children of the MIREC Study mothers
Sample Size
- Number of Participants
- 1,959
- Number of Participants with Biological Samples
- 1,959
- Supplementary information about number of participants
-
MIREC-Birth: 1959 participants
MIREC-ID 6months: 525 participants
MIREC-CD3: 370 participants
MIREC-CD Plus Biomonitoring: 803 participants
MIREC-CD Plus Neurodevelopment: 610 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MIREC - Children - Birth |
|
|
2008 (September) | 2011 (October) |
| 1 | MIREC - Children - MIREC-ID Birth |
|
|
2010 (January) | 2011 (December) |
| 2 | MIREC - Children - MIREC-ID 6 months |
|
2010 (August) | 2012 (May) | |
| 3 | MIREC - Children - MIREC-CD3 |
|
2012 (August) | 2014 (March) | |
| 4 | MIREC - Children - MIREC-CD Plus Biomonitoring |
|
|
2013 (March) | 2015 (March) |
| 5 | MIREC – Children - MIREC-CD Plus Neurodevelopment |
|
|
2013 (April) | 2015 (March) |
| 6 | MIREC – Children - MIREC-ENDO |
|
|
2018 (January) | Ongoing |
MIREC - Fathers
The population is composed of the MIREC children’ fathers.
Selection Criteria
- Gender
-
Men only
- Countries
-
- Canada
- Canadian Provinces
-
- Alberta
- British Columbia
- Manitoba
- Nova Scotia
- Ontario
- Quebec
- Territory
-
Vancouver, Edmonton, Winnipeg, Sudbury, Ottawa, Kingston, Hamilton, Toronto, Montreal and Halifax.
Sources of Recruitment
- Specific Population
-
- Other specific population : Fathers of the MIREC Study children
Sample Size
- Number of Participants
- 1,648
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MIREC - Fathers - MIREC-ID Birth |
|
2010 (January) | 2011 (December) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2021-05-26T17:51:49.048