Mayo Clinic Study of Aging
The objectives of the Mayo Clinic Study of Aging were to determine in the population of Olmsted County:
- the prevalence of mild cognitive impairment;
- the incidence of mild cognitive impairment;
- the conversion rates from mild cognitive impairment to dementia or Alzheimer's disease;
- the risk factors for mild cognitive impairment;
- the risk factors for the progression from mild cognitive impairment to dementia or Alzheimer's disease;
- develop risk models to predict MCI or dementia (including Alzheimer's disease).
Overview
- Acronym
- MCSA
- Website
- MCSA
- Investigators
-
- Contacts
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General Design
- Study design
- Cohort
- Start - End Year
- 2004 -
- General Information on Follow Up (profile, frequency)
-
First recruitment started in October 2004; the replenishment of the cohort make up for attrition due to death, refusal, or inability to contact began in 2008 and 2009. Recruitment is ongoing to maintain a sample size of approximately 3,000. The follow-up interval was approximately 15 months.
- Recruitment Target
-
- Individuals
- Number of Participants
- No Limit
- Number of Participants with Biological Samples
- No Limit
- Supplementary information about number of participants
-
The goal is to maintain approximately 3,000 active participants.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
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Marker Paper
Roberts RO, Geda YE, Knopman DS, et al. The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics. Neuroepidemiology, 2008; 30(1): 58-69.
PUBMED 18259084Supplementary Information
Number with follow-up visits is shown below:
Visits Frequency Percent
-------------------------------
1+ 4801 100.00
2+ 3609 75.17
3+ 2499 52.05
4+ 1754 36.53
5+ 1261 26.27
6+ 849 17.68
7+ 562 11.71
8 125 2.60
Timeline
Populations
Olmsted County residents aged 70 to 89 years on October 1st 2004, were randomly selected from an enumeration of the County population using an age and sex stratified sampling scheme. Participants return for follow-up evaluations every 12-15 months on average.
Selection Criteria
- Minimum age
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70
- Maximum age
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89
- Countries
-
- United States of America
- Territory
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Olmsted County
- Health Status
-
- Persons with a confirmed diagnosis of dementia were initially excluded, but since 2014 are now being recruited where possible
- Persons who are terminally ill and unable to provide information, or are in hospice are not included.
Sample Size
- Number of Participants
- No Limit
- Supplementary information about number of participants
-
Over 4600 participants have been evaluated in person (face-to-face) evaluation since onset of the study.
Numbers of participants with one or more visits:
Baseline: 4801 participants
Follow-up 1: 3609 participants
Follow-up 2: 2499 participants
Follow-up 3: 1754 participants
Follow-up 4: 1261 participants
Follow-up 5: 849 participants
Follow-up 6: 562 participants
Follow-up 7: 125 participants
Over 2500 participants have undergone MRI, 1200 or more have at least one follow-up scan .
Over 1,400 have undergone MRI and PET scanning; 400 or more have at least one follow-up scan.
Lumber puncture to obtain cerebrospinal fluid has been performed in over 812 participants; 137 have at least one follow-up CSF samples.
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MCSA - 70-89 years old - Baseline |
|
|
2004 (October) | 2007 (July) |
| 1 | MCSA - 70-89 years old - Follow-up 1 |
|
|
2006 (January) | 2008 (October) |
| 2 | MCSA - 70-89 years old - Follow-up 2 |
|
|
2007 (April) | 2010 (January) |
| 3 | MCSA - 70-89 years old - Follow-up 3 |
|
|
2008 (July) | 2011 (April) |
| 4 | MCSA - 70-89 years old - Follow-up 4 |
|
|
2009 (October) | 2012 (July) |
| 5 | MCSA - 70-89 years old - Follow-up 5 |
|
|
2011 (January) | 2013 (October) |
| 6 | MCSA - 70-89 years old - Follow-up 6 |
|
|
2012 (April) | 2015 (January) |
| 7 | MCSA - 70-89 years old - Follow-up 7 |
|
|
2013 (July) | 2016 (April) |
Recruitment of a middle-aged cohort aged 50-69 years old began in 2012 and is ongoing.
Residents of Olmsted County aged 50 to 69 years in 2012, were randomly selected from an enumeration of the County population using an age and sex stratified sampling scheme. Participants return for follow-up evaluations every 12-15 months on average.
Selection Criteria
- Minimum age
-
50
- Maximum age
-
69
- Countries
-
- United States of America
- Territory
-
Olmsted County
- Health Status
-
- Persons with a confirmed diagnosis of dementia were initially excluded, but since 2014 are now being recruited where possible
- Persons who are terminally ill and unable to provide information, or are in hospice are not included.
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MCSA - 50-69 years old - Baseline |
|
|
2012 | 2014 |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
Areas of Information Collected per per Population and Data Collection Event
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|