Maternal Adversity, Vulnerability and Neurodevelopment
Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) project is a prospective community-based, pregnancy and birth cohort of Canadian mother-child dyads. The main objective of MAVAN project is to examine the pre- and postnatal influences, and their interaction, in determining individual differences in children development. The MAVAN project is designed to examine the consequences of fetal adversity as a function of the quality of the postnatal environment, focusing on mother-infant interactions.
Overview
- Acronym
- MAVAN
- Investigators
-
General Design
- Study design
- Cohort
- Start - End Year
- 2003 -
- General Information on Follow Up (profile, frequency)
-
Dyads are assessed longitudinally, with multiple assessments of both mother and child in home and laboratory across the child’s development. The mothers were recruited between 13 to 20 weeks and interviewed between 24 to 36 weeks of pregnancy while dyads were followed from three-month post-partum onward. Dyads were assessed at 3, 6, 12, 18 months, and yearly from age 24 months onwards.
- Recruitment Target
-
- Families
- Number of Participants
- 1,249
- Supplementary information about number of participants
-
Mothers: 627 participants
Children: 622 participants Data retention rate varies among study time points and assessments.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Paper
O'Donnell KA, Gaudreau H, Colalillo S, Steiner M, Atkinson L, Moss E, Goldberg S, Karama S, Matthews SG, Lydon JE et al. 2014. The maternal adversity, vulnerability and neurodevelopment project: theory and methodology. Can J Psychiatry. 59(9):497-508.
PUBMED 25565695Timeline
Populations
MAVAN - Montreal mothers
Pregnant women who were attending obstetric clinics in hospitals were recruited for the study (usually at 13 to 20 weeks’ gestation). Women were included in the study if they were 18 years of age or older, and fluent in either English or French.
Selection Criteria
- Gender
-
Women only
- Minimum age
-
18
- Pregnant Women
-
- Second trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Montreal
- Other Criteria
- Exclusion criteria included serious obstetric complications during the pregnancy or delivery of the child, extremely low birth weight, prematurity (less than 37 weeks of gestation), or any congenital diseases.
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Women were recruited from obstetric clinics.
Sample Size
- Number of Participants
- 337
- Supplementary information about number of participants
-
24-36 weeks pregnancy: 337 participants
Birth: 231 participants
3 months: 177 participants
6 months: 334 participants
12 months: 311 participants
18 months: 266 participants
24 months: 276 participants
36 months: 244 participants
48 months: 206 participants
60 months: 181 participants
72 months: 166 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MAVAN - Montreal mothers - 24-36 weeks pregnancy |
|
2003 | 2015 | |
| 1 | MAVAN - Montreal mothers - Birth |
|
2004 | 2015 | |
| 2 | MAVAN - Montreal mothers - 3 months |
|
2004 | 2016 | |
| 3 | MAVAN - Montreal mothers - 6 months |
|
2004 | 2016 | |
| 4 | MAVAN - Montreal mothers - 12 months |
|
2004 | 2016 | |
| 5 | MAVAN - Montreal mothers - 18 months |
|
2005 | 2016 | |
| 6 | MAVAN - Montreal mothers - 24 months |
|
2005 | 2016 | |
| 7 | MAVAN - Montreal mothers - 36 months |
|
2006 | 2016 | |
| 8 | MAVAN - Montreal mothers - 48 months |
|
2007 | 2016 | |
| 9 | MAVAN - Montreal mothers - 60 months |
|
2008 | 2016 | |
| 10 | MAVAN - Montreal mothers - 72 months |
|
2009 | 2016 |
MAVAN - Hamilton mothers
Pregnant women who were attending obstetric clinics in hospitals were recruited for the study (usually at 13 to 20 weeks’ gestation). Women were included in the study if they were 18 years of age or older, and fluent in either English or French.
Selection Criteria
- Gender
-
Women only
- Minimum age
-
18
- Pregnant Women
-
- Second trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
- Territory
- Hamilton
- Health Status
-
- In Hamilton a subsample of high-risk women was recruited when undergoing treatment for depression or anxiety.
- Other Criteria
- Exclusion criteria included serious obstetric complications during the pregnancy or delivery of the child, extremely low birth weight, prematurity (less than 37 weeks of gestation), or any congenital diseases.
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Most women were recruited from obstetric clinics. A subsample of high-risk women was recruited when undergoing treatment for depression or anxiety.
Sample Size
- Number of Participants
- 290
- Supplementary information about number of participants
-
24-36 weeks pregnancy: 252 participants
Birth: 288 participants
3 months: 233 participants
6 months: 226 participants
12 months: 211 participants
18 months: 204 participants
24 months: 196 participants
36 months: 196 participants
48 months: 179 participants
60 months: 161 participants
72 months: 121 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MAVAN - Hamilton mothers - 24-36 weeks prenatal |
|
2003 | 2015 | |
| 1 | MAVAN - Hamilton mothers - Birth |
|
2004 | 2015 | |
| 2 | MAVAN - Hamilton mothers - 3 months |
|
2004 | 2016 | |
| 3 | MAVAN - Hamilton mothers - 6 months |
|
2004 | 2016 | |
| 4 | MAVAN - Hamilton mothers - 12 months |
|
2004 | 2016 | |
| 5 | MAVAN - Hamilton mothers - 18 months |
|
2005 | 2016 | |
| 6 | MAVAN - Hamilton mothers - 24 months |
|
2005 | 2016 | |
| 7 | MAVAN - Hamilton mothers - 36 months |
|
2006 | 2016 | |
| 8 | MAVAN - Hamilton mothers - 48 months |
|
2007 | 2016 | |
| 9 | MAVAN - Hamilton mothers - 60 months |
|
2008 | 2016 | |
| 10 | MAVAN - Hamilton mothers - 72 months |
|
2009 | 2016 |
MAVAN - Montreal children
The Children population is composed of the infants of mothers recruited for the MAVAN study.
Selection Criteria
- Newborns
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Montreal
- Supplementary Information about selection criteria
-
The MAVAN study also include siblings of participants.
Sources of Recruitment
- Specific Population
-
- Other specific population : Children of mothers recruited in the study.
- Supplementary Information
-
In Montreal, there was an attempt to recruit families with children born with lower birth weights.
Sample Size
- Number of Participants
- 334
- Supplementary information about number of participants
-
Birth: 231 participants
3 months: 177 participants
6 months: 334 participants
12 months: 311 participants
18 months: 266 participants
24 months: 276 participants
36 months: 244 participants
48 months: 206 participants
60 months: 181 participants
72 months: 166 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MAVAN - Montreal children - Birth |
|
2003 | 2016 | |
| 1 | MAVAN - Montreal children - 3 months |
|
2004 | 2016 | |
| 2 | MAVAN - Montreal children - 6 months |
|
2004 | 2016 | |
| 3 | MAVAN - Montreal children - 12 months |
|
2004 | 2016 | |
| 4 | MAVAN - Montreal children - 18 months |
|
2005 | 2016 | |
| 5 | MAVAN - Montreal children - 24 months |
|
2005 | 2016 | |
| 6 | MAVAN - Montreal children - 36 months |
|
2007 | 2016 | |
| 7 | MAVAN - Montreal children - 48 months |
|
2007 | 2016 | |
| 8 | MAVAN - Montreal children - 60 months |
|
2008 | 2016 | |
| 9 | MAVAN - Montreal children - 72 months |
|
2009 | 2016 |
MAVAN - Hamilton children
The Children population is composed of the infants of mothers recruited for the MAVAN study.
Selection Criteria
- Newborns
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
- Territory
- Hamilton
- Supplementary Information about selection criteria
-
The MAVAN study also include siblings of participants.
Sources of Recruitment
- Specific Population
-
- Other specific population : Children of mothers recruited in the study
Sample Size
- Number of Participants
- 288
- Supplementary information about number of participants
-
Birth: 288 participants
3 months: 233 participants
6 months: 226 participants
12 months: 211 participants
18 months: 204 participants
24 months: 196 participants
36 months: 196 participants
48 months: 179 participants
60 months: 161 participants
72 months: 121 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MAVAN - Hamilton children - Birth |
|
2003 | 2016 | |
| 1 | MAVAN - Hamilton children - 3 months |
|
2004 | 2016 | |
| 2 | MAVAN - Hamilton children - 6 months |
|
2004 | 2016 | |
| 3 | MAVAN - Hamilton children - 12 months |
|
2004 | 2016 | |
| 4 | MAVAN - Hamilton children - 18 months |
|
2005 | 2016 | |
| 5 | MAVAN - Hamilton children - 24 months |
|
2005 | 2016 | |
| 6 | MAVAN - Hamilton children - 36 months |
|
2007 | 2016 | |
| 7 | MAVAN - Hamilton children - 48 months |
|
2007 | 2016 | |
| 8 | MAVAN - Hamilton children - 60 months |
|
2008 | 2016 | |
| 9 | MAVAN - Hamilton children - 72 months |
|
2009 | 2016 |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2023-08-10T18:18:33.012