Sydney Memory and Aging Study
The objectives of the Sydney MAS study are:
- To examine the clinical characteristiques and prevalence of mild cognitive impairment and related syndromes in non-demented older Australians;
- To determine the rate of change in cognitive function over time;
- To examine predictors of cognitive decline from sociodemographic, clinical, neuropsychological, neuroimaging, biochemical, genetics and proteomics perspectives;
- To assess behavioral and psychological symptoms in mild cognitive impairment.
Overview
- Acronym
- SydneyMAS
- Website
- SydneyMAS
- Investigators
-
- Contacts
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General Design
- Study design
- Cohort
- Start - End Year
- 2005 -
- General Information on Follow Up (profile, frequency)
-
The baseline assessment was repeated at two-yearly intervals, with repeat blood sampling and MRI scans occurring in waves 1, 2 and 4 (+ wave 7 for blood sample). In the intervening years, participants were contacted by telephone for a brief assessment.
- Recruitment Target
-
- Individuals
- Number of Participants
- 1,037
- Number of Participants with Biological Samples
- 943
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
MRI data (raw images and extracted features); blood-derived measures (e.g. genetics measures, proteomics).
Marker Papers
Sachdev PS, et al. The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years. Int Psychogeriatr, 2010; 22(8): 1248-64.
PUBMED 20637138Timeline
Population
The population is composed of individual aged 70 to 90 years and living in the community of Kingsford-Smith and Wentworth, New South Wales.
Selection Criteria
- Minimum age
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70
- Maximum age
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90
- Countries
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- Australia
- Territory
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Kingsford-Smith and Wentworth, New South Wales.
- Other Criteria
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Participants had to speak and write English sufficiently well to complete a psychometric assessment and were able to consent to participate.
The participants were excluded if they had a previous diagnosis of dementia, psychotic symptoms or a diagnosis of schizophrenia or bipolar disorder, multiple sclerosis, motor neuron disease, developmental disability, progressive malignancy, or if they had medical or psychological conditions that may have prevented them from completing assessments.Participants were excluded if they had a MMSE score of less than 24 at study entry or if they received a diagnosis of dementia after comprehensive assessment.
Sources of Recruitment
- General Population
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- Selected sample
- Supplementary Information
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Participants were recruited randomly through the electoral roll from two federal government areas.
Sample Size
- Number of Participants
- 1,037
- Number of Participants with Biological Samples
- 943
- Supplementary information about number of participants
-
Wave 1: Baseline assessment (1037 participants), blood tests (943 participants) and MRI (544 participants)
1-year phone interview: 970 participants
Wave 2: 2-year assessment (889 participants), blood tests (722 participants) and MRI (425 participants)
3-year phone interview: 839 participants
Wave 3: 4-year assessment (792 participants)
5-year phone interview: 751 participants
Wave 4: 6-year assessment (708 participants), blood tests (533 participants) and MRI (265 participants)
7-year phone interview: 644 participants
Wave 5: 8-year assessment (574 participants, under review)
9-year phone interview: 517 participants (under review)
Wave 6: 465 participants (under review)
11-year phone interview: 254 participants (ongoing)
Wave 7: 57 participants (ongoing)
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | SydneyMAS - Wave 1 |
|
|
2005 (September) | 2007 (December) |
| 1 | SydneyMAS - 1-year phone interview |
|
2006 (October) | 2008 (December) | |
| 2 | SydneyMAS - Wave 2 |
|
|
2007 (October) | 2009 (December) |
| 3 | SydneyMAS - 3-year phone interview |
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2008 (October) | 2010 (December) | |
| 4 | SydneyMAS - Wave 3 |
|
2009 (October) | 2011 (December) | |
| 5 | SydneyMAS - 5-year phone interview |
|
2010 (October) | 2012 (December) | |
| 6 | SydneyMAS - Wave 4 |
|
|
2011 (October) | 2014 (March) |
| 7 | SydneyMAS - 7-year phone interview |
|
2012 (October) | 2014 (December) | |
| 8 | SydneyMAS - Wave 5 |
|
2013 (October) | 2016 (March) | |
| 9 | SydneyMAS - 9-year phone interview |
|
2014 (November) | 2017 (March) | |
| 10 | SydneyMAS - Wave 6 |
|
2016 (March) | 2018 (September) | |
| 11 | SydneyMAS - 11-year phone interview |
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2017 (March) | Ongoing | |
| 12 | SydneyMAS - Wave 7 |
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2018 (September) | Ongoing |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
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Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
Areas of Information Collected per per Population and Data Collection Event
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|