Intergene - Lifestyle and Health
The InterGene research program started in 2001 with the examination of a population-based cohort of men and women aged 25-74, to be used as a 4th MONICA-Gothenburg survey. The cohort was re-examined 14 years later and then a new cohort of younger individuals was added, the “Young Heart” study.
The aim was to study the interplay between genetic and environmental determinants of health with emphasis on coronary heart disease.
Overview
- Acronym
- INTERGENE
- Website
- INTERGENE
- Investigators
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- Contacts
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General Design
- Study design
- Cohort
- Start - End Year
- 2001 - 2017
- General Information on Follow Up (profile, frequency)
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Baseline participants that were recruited in 2001 were followed up in 2005-2006 and re-examination in 2014 -2016. After 14 years, a new a new cohort of younger individuals was added, the “Young Heart” study. Swedish disease registries and registry linkage for follow-up of morbidity and mortality has been being updated regularly.
- Recruitment Target
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- Individuals
- Number of Participants
- 5,634
- Number of Participants with Biological Samples
- 5,620
- Supplementary information about number of participants
-
* A population-based random sample of subjects aged 24–74 at the time of sampling by 1 April 2001 (n= 3614). * A case-control of Coronary heart disease (CHD) cases, 31–75 year old patients discharged from the Sahlgrenska University Hospital in Gothenburg, Sweden (n=618). * First-degree biological relatives of cases with Coronary heart disease (CHD) (n=377). * Young Heart cohort. A new cohort of young subjects recruited in 2016.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
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Marker Papers
Mehlig K, Berg C, Björck L, et al. Cohort profile: the INTERGENE study, Int. J. Epidemiology, 2017; 46(6) 1742-1743h.
PUBMED 28186561Berg C, Rosengren A, Aires N, et al. Trends in overweight and obesity from 1985 to 2002 in Göteborg, West Sweden. Int J Obes (Lond), 2005; 29(8): 916-24.
PUBMED 15852045Berg CM, Lissner L, Aires N, et al. Trends in blood lipid levels, blood pressure, alcohol and smoking habits from 1985 to 2002: results from INTERGENE and GOT-MONICA. Eur J Cardiovasc Prev Rehabil, 2005; 12(2): 115-25.
PUBMED 15785296Mehlig K, Blomqvist I, Klingberg S, et al. Secular trends in diet-related greenhouse gas emission estimates since 2000 - a shift towards sustainable diets in Sweden. Public Health Nutr, 2021; 24(12): 3916-3921.
PUBMED 33059781Mehlig K, Nehmtallah T, Rosvall M, et al. Negative life events predict weight gain in a 13-year follow-up of an adult Swedish population. J Psychosom Res, 2020; 132:109973.
PUBMED 32146250Timeline
Populations
INTERGENE - Cohort
The population is composed of men and women between 24 and 74 years old, living in the south-western part of Sweden and recruited from the general population.
Selection Criteria
- Minimum age
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24
- Maximum age
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74
- Countries
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- Sweden
- Territory
- Gothenburg and rural areas of the south-western part of Sweden.
Sources of Recruitment
- General Population
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- Volunteer enrolment
- Supplementary Information
-
The eligible members of the population-based sample received a postal invitation and information about the study. Questionnaires were filled on the screening day and a supplemental questionnaire on psychosocial factors was sent by mail.
Sample Size
- Number of Participants
- 3,614
- Number of Participants with Biological Samples
- 3,614
- Supplementary information about number of participants
-
- Baseline: 3614 participants
- Follow-up 1: 2478 participants
- Follow-up 2: 1276 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | INTERGENE - Cohort- baseline |
|
|
2001 (April) | 2004 (December) |
| 1 | INTERGENE - Cohort - follow-up 1 |
|
2005 (January) | 2006 (December) | |
| 2 | INTERGENE - Cohort - follow-up 2 |
|
|
2014 (February) | 2016 (May) |
INTERGENE - CHD Cases
The sample of cases with Coronary heart disease (CHD) is composed by patients between 31 and 75 years old who had specific diagnoses and survived at least 21 days after hospitalization, all discharged from the Sahlgrenska University Hospital in Gothenburg, Sweden.
Selection Criteria
- Minimum age
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31
- Maximum age
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75
- Countries
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- Sweden
- Territory
- Gothenburg and south-western part of Sweden
- Health Status
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- Coronary heart disease (CHD) diagnos and survived at least 21 days after hospitalization.
Sources of Recruitment
- Specific Population
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- Clinic patients
- Supplementary Information
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Discharged from the Sahlgrenska University Hospital in Gothenburg.
Sample Size
- Number of Participants
- 618
- Number of Participants with Biological Samples
- 618
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | INTERGENE - CHD Cases - baseline |
|
|
2001 (April) | 2004 (December) |
INTERGENE - Relatives of CHD cases
The population is composed by first-degree relatives to patients with a diagnosis of Coronary heart disease (CHD).
Selection Criteria
- Minimum age
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18
- Maximum age
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76
- Countries
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- Sweden
- Territory
- Gothenburg and rural areas of the south-western part of Sweden.
- Other Criteria
- First degree relatives to CHD cases.
Sources of Recruitment
- Other Sources
- First degree relatives to members of the control group.
Sample Size
- Number of Participants
- 377
- Number of Participants with Biological Samples
- 363
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | INTERGENE - Relatives of CHD cases - baseline |
|
|
2001 (April) | 2004 (December) |
INTERGENE - Cohort Young Hearth
The population is composed by individuals between 24 and 40 years old, living in the south-western part of Sweden and recruited from the general population.
Selection Criteria
- Minimum age
-
24
- Maximum age
-
40
- Countries
-
- Sweden
- Territory
- Gothenburg and rural areas of the south-western part of Sweden.
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Supplementary Information
-
The eligible members of the population-based sample received a postal invitation and information about the study. Questionnaires were filled on the screening day and a supplemental questionnaire on psychosocial factors was sent by mail.
Sample Size
- Number of Participants
- 1,025
- Number of Participants with Biological Samples
- 1,025
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | INTERGENE - Cohort Young Hearth – baseline |
|
|
2016 | 2017 |
Participating Studies
| Acronym | Name | Study design | Countries |
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Harmonization Initiatives Included
| Acronym | Name |
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Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2023-08-10T18:18:50.707