GESTation and Environment
The initial objective of this study was to investigate the association between maternal blood PBDE concentrations measured in early pregnancy and serum thyroid hormone levels assessed at less than 20 weeks of pregnancy, at delivery, and in cord blood.
More specifically the study aimed to:
- examine the relationship between PBDE concentrations and thyroid hormones and their metabolites in maternal and cord blood;
- determine the dose-response relationship between Mn, Cd, Pb, PCB, PBDE and Hg concentrations at birth, and psychomotor scores of children taking into account potential confounding factors including postnatal exposures;
- determine whether prenatal exposure to PBDE flame retardants is associated with MRI abnormalities in brain function and connectivity and with ADHD behaviors and diagnosis;
- determine whether prenatal exposure to halogenated non-PBDE flame retardants is associated with MRI abnormalities in brain function and connectivity and with ADHD behaviors and diagnosis; and
- explore whether the levels of PBDEs and their substitutes, measured in both blood and stools during childhood, are associated with MRI brain measures, neurobehaviors and ADHD diagnosis, directly or via alterations of the gut microbiome.
Overview
- Acronym
- GESTE
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2007 -
- General Information on Follow Up (profile, frequency)
-
Women were enrolled at less than 20 weeks of pregnancy, at their first prenatal care visit, with follow-up at delivery. Other women were recruited at delivery. All children were then followed at 2 years, 6-7 years and at 8-12 years.
- Recruitment Target
-
- Families
- Number of Participants
- 1,561
- Number of Participants with Biological Samples
- 1,561
- Supplementary information about number of participants
-
Mothers: 800 participants
Children: 761 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Papers
Abdelouahab N, Langlois MF, Lavoie L, Corbin F, Pasquier JC, Takser L. 2013. Maternal and cord-blood thyroid hormone levels and exposure to polybrominated diphenyl ethers and polychlorinated biphenyls during early pregnancy. AJE (2013) 178(5):701-713.
PUBMED 23924579Supplementary Information
Serme-Gbedo YK, Abdelouahab N, Pasquier JC, Cohen AA, Takser L. Maternal levels of endocrine disruptors, polybrominated diphenyl ethers, in early pregnancy are not associated with lower birth weight in the Canadian birth cohort GESTE. Environ Health. 2016 Apr 12;15:49.
PMID: 27068391
PMID: 27068391
Timeline
Populations
GESTE - Mothers
The population is composed of pregnant women who were enrolled at less than 20 weeks of pregnancy, at their first prenatal care visit at the University Hospital Center of Sherbrooke. A second sample of women was recruited at delivery.
Selection Criteria
- Gender
-
Women only
- Minimum age
-
18
- Pregnant Women
-
- First trimester
- Second trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Sherbrooke
- Health Status
-
- No known thyroid disease
- Other Criteria
- Gestational age less than 20 weeks or at delivery.
- Supplementary Information about selection criteria
-
After verification of medical files, a post hoc exclusion criterion was added: use of medication known to affect thyroid hormone levels.
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Participants were recruited at their first care visit. A second sample of women was recruited at delivery.
Sample Size
- Number of Participants
- 800
- Number of Participants with Biological Samples
- 800
- Supplementary information about number of participants
-
20 weeks gestation: 400 participants
Delivery: 761 participants
6-7 years: 367 participants
8-12 years: 161 participants (ongoing)
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | GESTE - Mothers - < 20 weeks gestation |
|
|
2007 (September) | 2008 (December) |
| 1 | GESTE - Mothers - Delivery |
|
|
2008 (February) | 2009 (July) |
| 2 | GESTE - Mothers - Follow-up at 6-7 years |
|
|
2014 (July) | 2016 (November) |
| 3 | GESTE - Mothers - Follow-up at 8-12 years |
|
2017 (September) | 2023 (March) |
GESTE - Children
Children of the women in the GESTE study. Born between February 2008 and July 2009.
Selection Criteria
- Newborns
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Sherbrooke
Sources of Recruitment
- Specific Population
-
- Other specific population : Children of the women in the GESTE study.
Sample Size
- Number of Participants
- 761
- Number of Participants with Biological Samples
- 761
- Supplementary information about number of participants
-
Delivery: 761 participants
2 years: 291 participants
6-7 years: 367 participants
8-12 years: 161 participants (ongoing)
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | GESTE - Children - Delivery |
|
|
2008 (February) | 2009 (July) |
| 1 | GESTE - Children - Follow-up at 2 years old |
|
|
2010 (February) | 2011 (July) |
| 2 | GESTE - Children - Follow-up at 6-7 years old |
|
|
2014 (July) | 2016 (November) |
| 3 | GESTE - Children - Follow-up at 8-12 years old |
|
|
2017 (September) | 2023 (March) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2022-06-21T07:06:09.088