The 10/66 Dementia Research Group Population-Based Cohort Study
10/66 aims to provide a detailed evidence-base to inform the development and implementation of policies for improving the health and social welfare of older people in low and middle income countries, particularly the 14 million people with dementia, their relatives and carers.
The 10/66 population-based study aims to:
• Create a publicly accessible data archive;
• Use these data for comparative descriptive analyses of dementia prevalence, and its associated impact;
• Model dementia prevalence, examining the effects of age, education, literacy, socioeconomic status, urban vs rural setting, historical levels of infant mortality, economic development and industrialization;
• Estimate the annual incidence rate of dementia and its subtypes, by age group, education and centre, and to investigate risk factors for incident dementia and Alzheimer’s disease;
• Confirm the predictive validity of the survey dementia diagnoses and Mild Cognitive Impairment (MCI) through follow-up of all dementia and MCI cases.
Overview
- Acronym
- 10/66
- Website
- 10/66
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2003 -
- General Information on Follow Up (profile, frequency)
-
The first wave of surveys started in 2003. A first follow-up was carried out between 2007 and 2010 and a third wave of assessment using an extended form of the basic 10/66 survey will start in 2016.
All the countries with the exception of urban India had a full follow-up. In India, a follow-up was only carried out for the mortality outcome.
- Recruitment Target
-
- Individuals
- Number of Participants
- 15,901
- Number of Participants with Biological Samples
- 9,178
- Supplementary information about number of participants
-
By site, the numbers and proportions providing samples were: Cuba (2 355, 80.4% of those participating in the survey), Dominican Republic (1 483, 73.8%), Puerto Rico (1 584, 78.8%), Venezuela (1 284, 65.3%), urban Peru (755, 54.7%), urban Mexico (822, 82.0%), and rural Mexico (895, 89.5%)
- Supplementary Information
-
Prince, M., Ferri, C. P., Acosta, D., Albanese, E., Arizaga, R., Dewey, M., . . . Uwakwe, R. (2007). The protocols for the 10/66 dementia research group population-based research programme. BMC Public Health, 7, 165. PUBMED 17659078
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Paper
A. Matthew Prina*, Daisy Acosta, Isaac Acostas, Mariella Guerra, YueqinHuang, AT Jotheeswaran, Ivonne Z. Jimenez-Velazquez, ZhaoruiLiu, Juan J LlibreRodriguez, Aquiles Salas, Ana Luisa Sosa, Joseph D Williams, Martin Prince. (2016) CohortProfile: the 10/66 study. International Journal of Epidemiology. In press
PUBMED 27154633Timeline
Populations
10/66 - Cuba
Participants are residents of Cuba, age 65 years or older at the time of recruitment.
Selection Criteria
- Minimum age
-
65
- Countries
-
- Cuba
- Territory
- One catchment area comprising sites in Havana and Matanzas
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Sample Size
- Number of Participants
- 2,813
- Number of Participants with Biological Samples
- 2,355
- Supplementary information about number of participants
-
Baseline: 2813 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 10/66 - Cuba - Baseline |
|
|
2003 (November) | 2005 (July) |
| 1 | 10/66 - Cuba - Follow-up 1 |
|
|
2008 (April) | 2010 (May) |
10/66 - India
Participants are residents of India, age 65 years or older at the time of recruitment.
Selection Criteria
- Minimum age
-
65
- Countries
-
- India
- Territory
- Chennai
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Sample Size
- Number of Participants
- 2,004
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 10/66 - India - Baseline |
|
2004 (March) | 2006 (February) | |
| 1 | 10/66 - India - Follow-up 1 |
|
|
2008 (July) | 2008 (September) |
10/66 - Urban China
Participants are residents of urban China, age 65 years or older at the time of recruitment.
Selection Criteria
- Minimum age
-
65
- Countries
-
- China
- Territory
- Xicheng, Beijing province
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Sample Size
- Number of Participants
- 1,160
- Supplementary information about number of participants
-
Baseline: 1160 participants
Follow-up 1: 1160 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 10/66 - Urban China - Baseline |
|
|
2004 (April) | 2004 (December) |
| 1 | 10/66 - Urban China - Follow-up 1 |
|
|
2009 (May) | 2009 (December) |
10/66 - Rural China
Participants are residents of rural China, age 65 years or older at the time of recruitment.
Selection Criteria
- Minimum age
-
65
- Countries
-
- China
- Territory
- Daxing, Beijing province
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Sample Size
- Number of Participants
- 1,002
- Supplementary information about number of participants
-
Baseline: 1002 participants
Follow-up 1: 1002 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 10/66 - Rural China - Baseline |
|
|
2004 (April) | 2005 (February) |
| 1 | 10/66 - Rural China - Follow-up 1 |
|
|
2009 (July) | 2009 (November) |
10/66 - Dominican Republic
Participants are residents of Dominican Republic, age 65 years or older at the time of recruitment.
Selection Criteria
- Minimum age
-
65
- Countries
-
- Dominican Republic
- Territory
- Santo Domingo
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Sample Size
- Number of Participants
- 2,011
- Number of Participants with Biological Samples
- 1,483
- Supplementary information about number of participants
-
Baseline: 2011 participants
Follow-up 1: 1706 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 10/66 - Dominican Republic - Baseline |
|
|
2004 (September) | 2005 (September) |
| 1 | 10/66 - Dominican Republic - Follow-up 1 |
|
|
2009 (June) | 2010 (November) |
10/66 - Venezuela
Participants are residents of Venezuela, age 65 years or older at the time of recruitment.
Selection Criteria
- Minimum age
-
65
- Countries
-
- Venezuela
- Territory
- Caracas
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Sample Size
- Number of Participants
- 1,965
- Number of Participants with Biological Samples
- 1,284
- Supplementary information about number of participants
-
Baseline: 1965 participants
Follow-up 1: 507 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 10/66 - Venezuela - Baseline |
|
|
2005 (February) | 2006 (July) |
| 1 | 10/66 - Venezuela - Follow-up 1 |
|
|
2009 (August) | 2010 (August) |
10/66 - Urban Peru
Participants are residents of urban Peru, age 65 years or older at the time of recruitment.
Selection Criteria
- Minimum age
-
65
- Countries
-
- Peru
- Territory
- Lima
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Sample Size
- Number of Participants
- 1,381
- Number of Participants with Biological Samples
- 755
- Supplementary information about number of participants
-
Baseline: 1381 participants
Follow-up 1: 1697 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 10/66 - Urban Peru - Baseline |
|
|
2005 (March) | 2006 (August) |
| 1 | 10/66 - Urban Peru - Follow-up 1 |
|
|
2009 (September) | 2010 (July) |
10/66 - Rural Peru
Participants are residents of rural Peru, age 65 years or older at the time of recruitment.
Selection Criteria
- Minimum age
-
65
- Countries
-
- Peru
- Territory
- Canete Province
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Sample Size
- Number of Participants
- 552
- Supplementary information about number of participants
-
Baseline: 552 participants
Follow-up 1: 552 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 10/66 - Rural Peru - Baseline |
|
|
2005 (December) | 2006 (April) |
| 1 | 10/66 - Rural Peru - Follow-up 1 |
|
|
2009 (September) | 2009 (December) |
10/66 - Urban Mexico
Participants are residents of urban Mexico, age 65 years or older at the time of recruitment.
Selection Criteria
- Minimum age
-
65
- Countries
-
- Mexico
- Territory
- Mexico city
Sample Size
- Number of Participants
- 1,003
- Number of Participants with Biological Samples
- 822
- Supplementary information about number of participants
-
Baseline: 1003 participants
Follow-up 1: 911 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 10/66 - Urban Mexico - Baseline |
|
|
2005 (December) | 2007 (March) |
| 1 | 10/66 - Urban Mexico - Follow-up 1 |
|
|
2009 (January) | 2010 (May) |
10/66 - Rural Mexico
Participants are residents of rural Mexico, age 65 years or older at the time of recruitment.
Selection Criteria
- Minimum age
-
65
- Countries
-
- Mexico
- Territory
- Morelos State
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Sample Size
- Number of Participants
- 1,000
- Number of Participants with Biological Samples
- 895
- Supplementary information about number of participants
-
Baseline: 1000 participants
Follow-up 1: 933 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 10/66 - Rural Mexico - Baseline |
|
|
2006 (August) | 2007 (February) |
| 1 | 10/66 - Rural Mexico - Follow-up 1 |
|
|
2009 (August) | 2010 (April) |
10/66 - Puerto Rico
Participants are residents of Puerto Rico, age 65 years or older at the time of recruitment.
Selection Criteria
- Minimum age
-
65
- Countries
-
- Puerto Rico
- Territory
- Bayamon
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Mapping of the catchment areas was carried out within specified boundaries, and households were allocated household identification numbers. Enumeration was carried out by door-knocking all households in the catchment area to identify potentially eligible participants (those aged 65 years or over on a census date) who were allocated participant identification numbers.
Sample Size
- Number of Participants
- 2,009
- Number of Participants with Biological Samples
- 1,584
- Supplementary information about number of participants
-
Baseline: 2009 participants
Follow-up 1: 1567 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 10/66 - Puerto Rico - Baseline |
|
|
2007 (August) | 2009 (January) |
| 1 | 10/66 - Puerto Rico - Follow-up 1 |
|
|
2012 (May) | 2013 (October) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2020-07-28T17:36:23.784