CANVAS: COVID Vaccine Active Safety Surveillance
The objectives of this study are:
* To identify common and uncommon health events associated with COVID-19 vaccination and to estimate their incidence by vaccine product, age, sex, and other
demographic and health-related factors.
* To estimate in individuals vaccinated against COVID-19 the frequency of health events of sufficient severity to cause medical consultation, work absenteeism, or prevent daily activities for each COVID-19 vaccine.
* To determine whether severe health event rates for each COVID-19 vaccine are higher than severe health
event rates in an unvaccinated control group.
Overview
- Acronym
- CANVAS-COVID
- Website
- CANVAS-COVID
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2020 -
- General Information on Follow Up (profile, frequency)
-
Participants were followed-up 1 week after dose 1, 1 week after dose 2 and 7 months after dose 1. The control survey collected data in the last 7 and 28 days and 6 months in unvaccinated participants.
- Recruitment Target
-
- Individuals
- Number of Participants
- 770,000
- Supplementary Information
-
Medically attended events are followed up by telephone.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Papers
Bettinger JA, Sadarangani M, De Serres G, et al. The Canadian National Vaccine Safety Network: surveillance of adverse events following immunisation among individuals immunised with the COVID-19 vaccine, a cohort study in Canada. BMJ Open, 2022;12: e051254
PUBMED 35058258Timeline
Populations
CANVAS-COVID - COVID-19 Vaccinated
The population is composed of COVID-19 vaccinated individuals, 4 years of age and older from Ontario, Quebec, British Columbia, Alberta, Nova Scotia, Yukon and Prince Edward Island.
Selection Criteria
- Minimum age
-
4
- Countries
-
- Canada
- Canadian Provinces
-
- Alberta
- British Columbia
- Nova Scotia
- Ontario
- Prince Edward Island
- Quebec
- Yukon
- Other Criteria
- Inclusion: Individuals who are vaccinated with at least one dose of a COVID-19 vaccine in the previous 8 days, with an active email address who are French or English speaking are included.
- Supplementary Information about selection criteria
-
In 2020 and 2021 participants followed were 12 years and older.
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Specific Population
-
- Other specific population : Vaccine registry
- Supplementary Information
-
Recruitment approaches vary at each site. However, three primary methods are used: * Passive recruitment of COVID-19 vaccinated individuals at the time of vaccination via posters and public health information provided to vaccine recipients. * Electronic invitation via the vaccination booking site when the vaccination appointment is made. * Electronic invitation via email from contact information in the vaccine registry.
Sample Size
- Number of Participants
- 720,000
- Supplementary information about number of participants
-
For each of the 3 vaccine products, the target sample size is 240 000 vaccinated participants.
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | CANVAS-COVID - COVID-19 Vaccinated - Dose 1 survey |
|
2020 (December) | Ongoing | |
| 1 | CANVAS-COVID - COVID-19 Vaccinated - Dose 2 survey |
|
2021 (January) | Ongoing | |
| 2 | CANVAS-COVID - COVID-19 Vaccinated - 6 month survey |
|
2021 (June) | Ongoing |
CANVAS-COVID - COVID-19 Unvaccinated
The population is composed of unvaccinated individuals, 4 years of age and older from Ontario, Quebec, British Columbia, Alberta, Nova Scotia, Yukon and Prince Edward Island.
Selection Criteria
- Minimum age
-
4
- Countries
-
- Canada
- Canadian Provinces
-
- Alberta
- British Columbia
- Nova Scotia
- Ontario
- Prince Edward Island
- Quebec
- Yukon
- Other Criteria
- Inclusion: Individuals who are not vaccinated with any COVID-19 vaccine, with an active email address who are French or English speaking.
- Supplementary Information about selection criteria
-
In 2020 and 2021 participants followed were 12 years and older.
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Specific Population
-
- Other specific population : CANImmunize digital immunisation platform.
- Participants from Existing Studies
-
- The Canadian National Vaccine Safety Study (CANVAS)
- Supplementary Information
-
The methods for participants recruitment were: * Through existing CANVAS sites where previous CANVAS participants have agreed to be contacted about research. * Through CANImmunize invitations (CANIm- munize is a digital immunisation platform. CANImmu- nize and CANVAS have previously partnered to build and test a proof-of-concept stand-alone pilot app for CANVAS safety reporting. CANImmunize can identify account users (approximately 100 000) by demographics and invite them to participate in the CANVAS-COVID control survey (www.canimmunize.ca) as controls. * Through publicity to direct individuals via www.CANVAS-COVID.ca. * Through volunteer research databases.
Sample Size
- Number of Participants
- 50,000
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | CANVAS-COVID - COVID-19 Unvaccinated - 7 days survey |
|
2020 (December) | Ongoing | |
| 1 | CANVAS-COVID - COVID-19 Unvaccinated - 28 days survey |
|
2021 (January) | Ongoing | |
| 2 | CANVAS-COVID - COVID-19 Unvaccinated - 6 month survey |
|
2021 (June) | Ongoing |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2024-04-01T09:10:08.125