Identification of Underlying Factors Influencing the Immune Response to SARS-CoV-2 among Workers and Residents in Long-term Care Homes: A Multi-province Study
The overall objective of this study is to determine the humoral, sociodemographic and health-related risk factors that increase the likelihood of a SARS-CoV-2 infection, potential re-infection, and serious outcomes (including hospitalization and death) from COVID-19 among workers and residents in long-term care (LTC) homes. The specific objectives of this study are to:
* Create a multi-province study cohort;
* Measure serological markers in LTC workers and residents from dried blood spots (DBS) samples and compare the immune response in individuals with natural versus vaccine-acquired immunity;
* Explore the humoral immunity in vaccinated LTC workers, residents, and family members/caregivers of LTC residents against emerging variants of concern (VOCs). Further ability to neutralize VOCs or detect VOC receptor binding domains in a standard enzyme-linked immunosorbent assay (ELISA) will be assessed;
* Link data on virus neutralization and serological markers, vaccination records, and key social determinants of health using a survey to population-level healthcare administrative databases such as L'institut de la Statistique du Québec (ISQ), Institute for Clinical Evaluative Sciences (ICES) in Ontario, and Population Data BC to examine long-term health and healthcare outcomes following vaccination;
* Examine the association between humoral immunity (both natural and vaccine-acquired immunity), sociodemographic, health, and workplace factors with incidence of SARS-CoV-2 infections, as well as re-infections, ascertained through provincial COVID-19 testing data, and their influences on outcomes following a SARS-CoV-2 infection, including the odds of hospitalization, admission to an intensive care unit (ICU), use of mechanical ventilation, and death;
* Use regression and machine learning approaches to develop prediction models for SARS-CoV-2 infection, potential re-infection, and severe adverse outcomes of COVID-19, based on risk factors identified in Objectives 3 and 4.
Overview
- Acronym
- C19-IS
- Website
- C19-IS
- Investigators
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- Contacts
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General Design
- Study design
- Other : Prospective cohort
- Start - End Year
- 2021 - 2023
- General Information on Follow Up (profile, frequency)
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Participants complete questionnaires and provide a DBS sample first month post 3rd and/or 4th dose administration at the first timepoint and are followed-up every 3 months for a period of 18 months.
- Recruitment Target
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- Individuals
- Number of Participants
- 2,449
- Number of Participants with Biological Samples
- 2,449
- Supplementary information about number of participants
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1,863 participants from Ontario and 586 from British Columbia. (participant’s survey without any blood sample collection at any timepoint will be excluded from final analysis)
- Supplementary Information
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Recruitment in Ontario and British Columbia will include LTC homes that have and have not experienced a COVID-19 outbreak.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
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Timeline
Populations
C19-IS - LTC Workers
The population consists of workers over the age of 19 years, working in long-term care (LTC) homes in Ontario and British Columbia, with or without a history of SARS-CoV-2 infection.
Selection Criteria
- Minimum age
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19
- Countries
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- Canada
- Canadian Provinces
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- British Columbia
- Ontario
- Other Criteria
- Participant’s survey without any blood sample collection at any timepoint will be excluded from final analysis
Sources of Recruitment
- Specific Population
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- Other specific population : Long-term care homes workers
Sample Size
- Number of Participants
- 1,504
- Number of Participants with Biological Samples
- 1,504
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | C19-IS - LTC Workers - Timepoint 1 |
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2021 (June) | 2021 (June) |
| 1 | C19-IS - LTC Workers - Timepoint 2 |
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2021 (September) | 2021 (September) |
| 2 | C19-IS - LTC Workers - Timepoint 3 |
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2021 (December) | 2021 (December) |
| 3 | C19-IS - LTC Workers - Timepoint 4 |
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2022 (March) | 2022 (March) |
| 5 | C19-IS - LTC Workers - Timepoint 5 |
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2022 (June) | 2022 (June) |
| 5 | C19-IS - LTC Workers - Timepoint 6 |
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2022 (September) | 2022 (September) |
C19-IS - LTC Residents
The population consists of residents, over the age of 19, in long-term care (LTC) homes in Ontario and British Columbia, vaccinated with one of the COVID-19 vaccines and either with or without a history of SARS-CoV-2 infection.
Selection Criteria
- Minimum age
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19
- Countries
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- Canada
- Canadian Provinces
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- British Columbia
- Ontario
- Other Criteria
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Inclusion: French-speaking
Exclusion: LTC residents who do not have the capacity to provide consent and whose authorized legal representative(s)/substitute decision maker decline consent
Sources of Recruitment
- Specific Population
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- Other specific population : Long-term care homes residents
Sample Size
- Number of Participants
- 639
- Number of Participants with Biological Samples
- 639
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | C19-IS - LTC Residents - Timepoint 1 |
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2021 (June) | 2021 (June) |
| 1 | C19-IS - LTC Residents - Timepoint 2 |
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2021 (September) | 2021 (September) |
| 2 | C19-IS - LTC Residents - Timepoint 3 |
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2021 (December) | 2021 (December) |
| 3 | C19-IS - LTC Residents - Timepoint 4 |
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2022 (March) | 2022 (March) |
| 4 | C19-IS - LTC Residents - Timepoint 5 |
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2022 (June) | 2022 (June) |
| 5 | C19-IS - LTC Residents - Timepoint 6 |
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2022 (September) | 2022 (September) |
C19-IS - LTC Caregivers
The population consists of caregivers working in long-term care (LTC) homes and family members of LTC residents participating in the study, who are over 19 years of age, living in Ontario and British Columbia and either with or without a history of SARS-CoV-2 infection.
Selection Criteria
- Minimum age
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19
- Countries
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- Canada
- Canadian Provinces
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- British Columbia
- Ontario
Sources of Recruitment
- Specific Population
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- Other specific population : Professional long-term care caregivers and family members of participating long-term care residents
Sample Size
- Number of Participants
- 306
- Number of Participants with Biological Samples
- 306
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | C19-IS - LTC Caregivers - Timepoint 1 |
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2021 (June) | 2021 (June) |
| 1 | C19-IS - LTC Caregivers - Timepoint 2 |
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2021 (September) | 2021 (September) |
| 2 | C19-IS - LTC Caregivers - Timepoint 3 |
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2021 (December) | 2021 (December) |
| 3 | C19-IS - LTC Caregivers - Timepoint 4 |
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2022 (March) | 2022 (March) |
| 4 | C19-IS - LTC Caregivers - Timepoint 5 |
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2022 (June) | 2022 (June) |
| 5 | C19-IS - LTC Caregivers - Timepoint 6 |
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2022 (September) | 2022 (September) |
Participating Studies
| Acronym | Name | Study design | Countries |
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Harmonization Initiatives Included
| Acronym | Name |
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Datasets
| Name | Data Collection Events | Variables |
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Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
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Last Update: 2024-02-26T16:54:05.534