3D Study - Design, Develop, Discover
The main objective of the 3D study is to create a large pregnancy and birth cohort, allowing for the assessment of the effects of combined prenatal exposure on both birth outcomes and longer-term infant and child health.
The specific objectives are to:
* Determine the effects of pre- and post-natal exposures to environmental contaminants, nutritional factors and psychosocial stress on pregnancy and neurodevelopmental outcomes;
* Assess the contribution of social, genetic, epigenetic, nutritional and environmental factors to the etiology and outcomes of IUGR and preterm birth;
* Assess the effects of assisted reproductive technologies (ART) on indicators of epigenetic modifications, and the relationship between such epigenetic changes and child neurodevelopmental, cardiovascular, and metabolic outcomes; and
* Understand the mechanisms linking children's early development with mental health after the transition to formal school by examining the challenges and available resources during the transition from preschool to school, and evaluating the child’s adjustment to school and his/her new environment (3D-Transition study) .
Overview
- Acronym
- 3D
- Website
- 3D
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2010 -
- General Information on Follow Up (profile, frequency)
-
Pregnant women and their partners were recruited during the first trimester of pregnancy (8-14 weeks) and followed-up at mid (20–24 weeks) and late (32–35 weeks) pregnancy, and at delivery. Postnatal visits took place at 3 months, 1 year, and 2 years following the birth. Follow-up resumed at 4, 5, 6, 7, 8 and 9 years after birth (3D-Transition Study).
- Recruitment Target
-
- Families
- Number of Participants
- 8,365
- Number of Participants with Biological Samples
- 5,700
- Supplementary information about number of participants
-
Mothers: 2456 participants
Children: 2456 participants
Partners: 2333 participants
Teachers: 1120 participants (623 children have at least one questionnaire completed by a teacher) - Supplementary Information
-
ClinicalTrials registration of both initial and follow-up protocols (respectively):
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
- On the study website : https://www.irnpqeo.ca/en/
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
The Ancillary Study Committee of the Integrated Research Network in Perinatology of Quebec and Eastern Ontario (IRNPQEO)
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
| Can leave the study facility | ||
| Can leave the country |
Codification, encryption
Cost
| Possible Access to Data | Variable Cost |
| Possible Access to Biosamples | Variable Cost |
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Case by case
Marker Papers
William DF, Shapiro GD, Audibert F, Dubois L, et al. 3D Cohort Study: The Integrated Research Network in Perinatology of Quebec and Eastern Ontario. Paediatric and Perinatal Epidemiology, 2016;30(6):623-632.
PUBMED 27781295Rioux C, Parent S, Castellanos-Ryan N, Archambault I, et al. The 3D-Transition Study: Objectives, Methods, and Implementation of an Innovative Planned Missing Data Design. American Journal of Epidemiology, 2021;190(11):2262-2274.
PUBMED 33987638Parent S, Lupien S, Herba CM, Dupéré V, et al. Children’s cortisol response to the transition from preschool to formal schooling: A review. Psychoneuroendocrinology, 2019;99:196-205.
PUBMED 30253327Timeline
Populations
3D - Mothers
The population is composed of 8 to 14 weeks pregnant women from the general population between 18 and 47 years of age, who are fluent in French or English, who were attending prenatal clinics (ultrasound, midwife and/or doctor’s clinics) during the first trimester of pregnancy and who plan to deliver in a study hospital.
Selection Criteria
- Gender
-
Women only
- Minimum age
-
18
- Maximum age
-
47
- Pregnant Women
-
- First trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Other Criteria
- Exclusion criteria: Multiple pregnancies, intention to donate or bank cord blood, intravenous drug users, or if the woman has any one or more of the following conditions: HIV+ status, renal disease with altered renal function, any collagen vascular disease requiring active treatment (e.g. lupus, scleroderma), epilepsy, cardiovascular disease, serious pulmonary disease, cancer, or severe hematologic disorder.
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Women were recruited between May 25, 2010 and August 30, 2012 at one of nine study centres during routine first-trimester prenatal visits to study hospitals and infertility clinics.
Sample Size
- Number of Participants
- 2,456
- Number of Participants with Biological Samples
- 2,357
- Supplementary information about number of participants
-
3D-Transition study: 939 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 3D - Mothers - Prenatal visit 1 (8 to 14 weeks) |
|
|
2010 (June) | 2012 (September) |
| 1 | 3D - Mothers - Prenatal visit 2 (20 to 24 weeks) |
|
|
2010 (August) | 2012 (November) |
| 2 | 3D - Mothers - Prenatal visit 3 (32 to 35 weeks) |
|
|
2010 (October) | 2013 (February) |
| 3 | 3D - Mothers - Delivery and immediate postpartum |
|
|
2010 (November) | 2013 (March) |
| 4 | 3D - Mothers - 3 months postpartum |
|
2011 (March) | 2013 (July) | |
| 5 | 3D - Mothers - 12 months postpartum |
|
2011 (December) | 2014 (March) | |
| 6 | 3D - Mothers - 24 months postpartum |
|
2013 (March) | 2015 (March) | |
| 7 | 3D - Mothers - Spring prekindergarten |
|
2017 (March) | 2018 (August) | |
| 8 | 3D - Mothers - Spring kindergarten |
|
2017 (March) | 2019 (August) | |
| 9 | 3D - Mothers - Fall kindergarten |
|
2017 (September) | 2018 (December) | |
| 10 | 3D - Mothers - Fall grade 1 |
|
2017 (September) | 2019 (December) | |
| 11 | 3D - Mothers - Spring grade 1 |
|
2018 (March) | 2020 (August) | |
| 12 | 3D - Mothers - Spring grade 2 |
|
2019 (March) | 2021 (August) | |
| 13 | 3D - Mothers - Spring grade 3 |
|
2020 (March) | 2021 (August) | |
| 14 | 3D - Mothers - Spring grade 4 |
|
2021 (March) | 2021 (August) |
3D - Partners
The population is composed of the partners of the mothers recruited for the 3D study.
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
Sources of Recruitment
- Specific Population
-
- Other specific population : Partners of the mothers recruited
- Supplementary Information
-
Women and their partners were recruited between May 25, 2010 and August 30, 2012 at one of nine study centres during routine first-trimester prenatal visits to study hospitals and infertility clinics.
Sample Size
- Number of Participants
- 2,333
- Number of Participants with Biological Samples
- 2,333
- Supplementary information about number of participants
-
3D-Transition study: 939 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 3D - Partners - Prenatal visit 1 (8 to 14 weeks) |
|
|
2010 (June) | 2012 (September) |
| 1 | 3D - Partners - 3 months postpartum |
|
2011 (March) | 2013 (July) | |
| 2 | 3D - Partners - 12 months postpartum |
|
2011 (December) | 2014 (March) | |
| 3 | 3D - Partners - 24 months postpartum |
|
2013 (March) | 2015 (March) | |
| 4 | 3D - Partners - Spring prekindergarten |
|
2017 (March) | 2018 (August) | |
| 5 | 3D - Partners - Spring kindergarten |
|
2017 (March) | 2019 (August) | |
| 6 | 3D - Partners - Fall kindergarten |
|
2017 (September) | 2018 (December) | |
| 7 | 3D - Partners - Fall grade 1 |
|
2017 (September) | 2019 (December) | |
| 8 | 3D - Partners - Spring grade 1 |
|
2018 (March) | 2020 (August) | |
| 9 | 3D - Partners - Spring grade 2 |
|
2019 (March) | 2021 (August) | |
| 10 | 3D - Partners - Spring grade 3 |
|
2020 (March) | 2021 (August) | |
| 11 | 3D - Partners - Spring grade 4 |
|
2021 (March) | 2021 (August) |
3D - Children
The population is composed of the children of mothers recruited for the 3D study.
Selection Criteria
- Newborns
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
Sources of Recruitment
- Specific Population
-
- Other specific population : Newborn children of the women enrolled in the study
Sample Size
- Number of Participants
- 2,456
- Number of Participants with Biological Samples
- 1,010
- Supplementary information about number of participants
-
3D-Transition study: 939 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 3D - Children - Delivery and immediate postpartum |
|
|
2010 (November) | 2013 (March) |
| 1 | 3D - Children - 3 months postpartum |
|
2011 (March) | 2013 (July) | |
| 2 | 3D - Children - 12 months postpartum |
|
2011 (December) | 2014 (March) | |
| 3 | 3D - Children - 24 months postpartum |
|
|
2013 (March) | 2015 (March) |
| 4 | 3D - Children - Spring prekindergarten |
|
|
2017 (March) | 2018 (August) |
| 5 | 3D - Children - Spring kindergarten |
|
|
2017 (March) | 2019 (August) |
| 6 | 3D - Children - Fall kindergarten |
|
|
2017 (September) | 2018 (December) |
| 7 | 3D - Children - Fall grade 1 |
|
|
2017 (September) | 2019 (December) |
| 8 | 3D - Children - Spring grade 1 |
|
2018 (March) | 2020 (August) | |
| 9 | 3D - Children - Spring grade 2 |
|
2019 (March) | 2021 (August) | |
| 10 | 3D - Children - Spring grade 3 |
|
2020 (March) | 2021 (August) | |
| 11 | 3D - Children - Spring grade 4 |
|
2021 (March) | 2021 (August) |
3D - Teachers
The population is composed of the main teachers of the children recruited for the 3D study.
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Other Criteria
- Occupation as teachers
Sources of Recruitment
- Specific Population
-
- Members of an association
Sample Size
- Number of Participants
- 1,120
- Supplementary information about number of participants
-
623 children have at least one questionnaire completed by a teacher
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | 3D - Teachers - Spring prekindergarten |
|
2017 (March) | 2018 (August) | |
| 1 | 3D - Teachers - Spring kindergarten |
|
2017 (March) | 2019 (August) | |
| 2 | 3D - Teachers - Fall kindergarten |
|
2017 (September) | 2018 (December) | |
| 3 | 3D - Teachers - Fall grade 1 |
|
2017 (September) | 2019 (December) | |
| 4 | 3D - Teachers - Spring grade 1 |
|
2018 (March) | 2020 (August) | |
| 5 | 3D - Teachers - Spring grade 2 |
|
2019 (March) | 2021 (August) | |
| 6 | 3D - Teachers - Spring grade 3 |
|
2020 (March) | 2021 (August) | |
| 7 | 3D - Teachers - Spring grade 4 |
|
2021 (March) | 2021 (August) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2024-02-26T16:25:29.565