Pediatric MS Tool-Kit
The Pediatric MS Tool-Kit is a set of methodological resources to guide pediatric MS researchers in designing study-specific questionnaires that are amendable to harmonized analyses. The short-term goals of the Tool-Kit are to improve exposure measurement in individual pediatric MS studies, and to enhance the comparability of results across studies. In the long-term the use of the Tool-Kit will facilitate harmonization of pediatric MS studies. Pediatric MS is very rare, and thus harmonization of data collected across multiple studies has the potential to greatly enhance our understanding of MS etiology, in general. Harmonization is one methodological approach that can be used to circumvent issues of small sample sizes, which is a problem encountered in pediatric MS studies. The Tool-Kit currently includes variables to assess the following MS risk factors: sun exposure, environmental tobacco smoke exposure and vitamin D intake.
The development of the Tool-Kit was funded by an operating grant from the US National Multiple Sclerosis Society (Grant# 5986412).
If you wish to use the Tool-Kit variables, please contact Sandra Magalhaes (contact information provided below).
Overview
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Relevant Papers
Magalhaes S, Banwell B, Bar-Or A, Fortier I, Hanwell HE, Lim M, Matt GE, Neuteboom RF, O’Riordan DL, Schneider PK, Pugliatti M, Shatenstein B, Tansey CM, Wassmer E, Wolfson C. A framework for measurement and harmonization of pediatric multiple sclerosis etiologic research studies: The Pediatric MS Tool-Kit. Mult Scler. 2019;25(8):1170-1177. PUBMED 29932341
Harmonization Initiatives
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Summary Statistics
Individual Studies
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Participating Networks
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