The Sepsis Canada Network is a nationally coordinated research network funded by the Canadian Institute for Health Research. Its three pillars aim to facilitate and conduct research to further understand the causes and improve the prevention, detection and management of sepsis. The three pillars are: (1) Population Health, Economics and Policy, (2) Advocacy, Health Literacy and Knowledge Transfer, and (3) Translational Biology and Clinical Trials. Numerous and diverse existing datasets can be used to study the epidemiology of sepsis, including administrative, clinical, laboratory, medication administration, population-based survey, and other data. Maximally leveraging existing data to study sepsis requires obtaining access to, and analyzing linked data. However, these datasets are distributed across Canada, some are not well known or understood by sepsis investigators, and it can be challenging to identify relevant datasets, obtain access, link and harmonize the data. As foundational infrastructure for advancing knowledge about the epidemiology of sepsis, this metadata catalog has been created of existing relevant Canadian datasets, delineating: data owner and custodian, years included, data sources, fields included, the precise definition and format of each data field, and other information. Such metadata, or ‘data about data’, are necessary for anyone seeking to use a dataset to perform an epidemiologic evaluation. This metadata catalog includes not only medical databases that can be used to identify clinical sepsis events, but also non-medical datasets containing diverse information about Canadians. Linking medical and nonmedical data enables exploration of a wide range of epidemiologic questions regarding sepsis.