Adult Changes in Thought Study
The Adult Changes in Thought (ACT) is a prospective cohort study that focuses on dementia and Alzheimer's disease. It aims to create a "living laboratory" to study aging and dementia in older adults.The ACT study collects a variety of detailed information on demographics, risk factors, lifestyle, genetics, comorbidities, and outcomes and shares these data with interested investigators throughout the world.
Overview
- Acronym
- ACT
- Investigators
-
- Contacts
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General Design
- Study design
- Cohort
- Start - End Year
- 1994 -
- General Information on Follow Up (profile, frequency)
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The participants are followed up with interviews every two years until diagnosis of dementia and/or Alzheimer's disease.
- Recruitment Target
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- Individuals
- Number of Participants
- 4,960 (No Limit)
- Number of Participants with Biological Samples
- 4,960 (No Limit)
- Supplementary information about number of participants
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The ACT study is made up of three cohorts:
From 1994-1996 we enrolled a cohort of 2,581 people aged 65 years and older without dementia.
From 2000-2002, we enrolled an expansion cohort of 811 people using the same inclusion criteria.
From 2004-present, we began continuous enrollment using the same inclusion criteria to replace attrition from dementia, dropout, and death. We have a consistent cohort of ~2000 at risk for dementia. The total current enrollment of all three groups is 4,960.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
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Marker Paper
Kukull WA, Higdon R, Bowen JD, et al. Dementia and Alzheimer Disease Incidence: A Prospective Cohort Study. Arch Neurol. 2002;59(11):1737-1746. doi:10.1001/archneur.59.11.1737.
PUBMED 12433261Timeline
Population
The study population consists of 2581 men and women aged 65 or greater, in the Seattle area.
Selection Criteria
- Minimum age
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65
- Countries
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- United States of America
- Territory
- Seattle
- Other Criteria
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Participants with an existing diagnosis of dementia or those who were in a skilled nursing community were excluded.
Sources of Recruitment
- Specific Population
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- Members of an association
- Supplementary Information
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Random sample of members of the Group Health Cooperative of Puget Sound
Sample Size
- Number of Participants
- 2,581
- Number of Participants with Biological Samples
- 2,581
- Supplementary information about number of participants
-
Recruitment 1: 2581 participants
Recruitment 2: 811 participants
Recruitment 3: Seeks to maintain population of approximately 2000 participants (ongoing)
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | ACT - Recruitment 1 |
|
|
1994 | 1996 |
| 1 | ACT - Follow-up |
|
1996 | 2014 | |
| 2 | ACT - Recruitment 2 |
|
|
2000 | 2002 |
| 3 | ACT - Recruitment 3 |
|
|
2004 | 2014 |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
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Datasets
| Name | Data Collection Events | Variables |
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Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
Areas of Information Collected per per Population and Data Collection Event
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
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